LRRK2-IN-2
LRRK2-IN-2 (compoubd 22) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of [1].
Product Specifications
CAS Number
[2641059-19-8]
UNSPSC
12352005
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lrrk2-in-2.html
Solubility
10 mM in DMSO
Smiles
FC1([C@@H](N2C(Cl)=C(C=N2)NC3=NC4=C(C=C(C([C@H]5[C@@H](CN([C@H]6[C@H](COC6)O)CC5)F)=C4)Cl)C=N3)C1)F
Molecular Formula
C23H23Cl2F3N6O2
Molecular Weight
543.37
References & Citations
[1]Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65 (1) :838-856.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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