Vanin-1-IN-2

Vanin-1-IN-2 is a potent vanin-1 inhibitor with an IC50 of 162 nM. Vanin-1 is a cell-surface-associated, glycosylphosphatidyl inositol (GPI) -anchored protein which is expressed at high levels in the kidney, liver, and small intestine[1].

Product Specifications

CAS Number

[2054952-13-3]

UNSPSC

12352005

Target

Pantetheinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/vanin-1-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CN=C(NCC2=CC=CN=C2)N=C1)C3=CC=CS3

Molecular Formula

C15H12N4OS

Molecular Weight

296.35

References & Citations

[1]Casimiro-Garcia A, et al. Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem. 2022;65 (1) :757-784.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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