Vanin-1-IN-2
Vanin-1-IN-2 is a potent vanin-1 inhibitor with an IC50 of 162 nM. Vanin-1 is a cell-surface-associated, glycosylphosphatidyl inositol (GPI) -anchored protein which is expressed at high levels in the kidney, liver, and small intestine[1].
Product Specifications
CAS Number
[2054952-13-3]
UNSPSC
12352005
Target
Pantetheinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/vanin-1-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN=C(NCC2=CC=CN=C2)N=C1)C3=CC=CS3
Molecular Formula
C15H12N4OS
Molecular Weight
296.35
References & Citations
[1]Casimiro-Garcia A, et al. Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem. 2022;65 (1) :757-784.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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