TC113
TC113 is a c (RGDyK) -Based conjugate of Gemcitabine (GEM) . TC113 could be internalized by A549 cells through integrin αvβ3. TC113 shows potent antiproliferative properties against WM266.4 and A549 cells[1].
Product Specifications
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tc113.html
Solubility
10 mM in DMSO
Smiles
FC1(F)[C@H](O)[C@@H](COC(NCCCC[C@@H](C(N[C@@H](CCCNC(N)=N)C(NC2)=O)=O)NC([C@H](NC([C@@H](NC2=O)CC(O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)O[C@H]1N4C=CC(N)=NC4=O
Molecular Formula
C37H50F2N12O13
Molecular Weight
908.86
References & Citations
[1]Chatzisideri T, et al. Integrin-Mediated Targeted Cancer Therapy Using c (RGDyK) -Based Conjugates of Gemcitabine. J Med Chem. 2022;65 (1) :271-284.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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