TC113
Product Specifications
UNSPSC Description
TC113 is a c(RGDyK)-Based conjugate of Gemcitabine (GEM). TC113 could be internalized by A549 cells through integrin αvβ3. TC113 shows potent antiproliferative properties against WM266.4 and A549 cells[1].
Target Antigen
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tc113.html
Solubility
10 mM in DMSO
Smiles
FC1(F)[C@H](O)[C@@H](COC(NCCCC[C@@H](C(N[C@@H](CCCNC(N)=N)C(NC2)=O)=O)NC([C@H](NC([C@@H](NC2=O)CC(O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)O[C@H]1N4C=CC(N)=NC4=O
Molecular Weight
908.86
References & Citations
[1]Chatzisideri T, et al. Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine. J Med Chem. 2022;65(1):271-284.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145314/TC113-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145314/
Clinical Information
No Development Reported
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