TC113

TC113 is a c (RGDyK) -Based conjugate of Gemcitabine (GEM) . TC113 could be internalized by A549 cells through integrin αvβ3. TC113 shows potent antiproliferative properties against WM266.4 and A549 cells[1].

Product Specifications

UNSPSC

12352005

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tc113.html

Solubility

10 mM in DMSO

Smiles

FC1(F)[C@H](O)[C@@H](COC(NCCCC[C@@H](C(N[C@@H](CCCNC(N)=N)C(NC2)=O)=O)NC([C@H](NC([C@@H](NC2=O)CC(O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)O[C@H]1N4C=CC(N)=NC4=O

Molecular Formula

C37H50F2N12O13

Molecular Weight

908.86

References & Citations

[1]Chatzisideri T, et al. Integrin-Mediated Targeted Cancer Therapy Using c (RGDyK) -Based Conjugates of Gemcitabine. J Med Chem. 2022;65 (1) :271-284.