Bis-Pro-5FU
Product Specifications
UNSPSC Description
Bis-Pro-5FU (Compound 4) is a 5-FU precursor that confers oral bioavailability and increase the safety profile of 5-Fluorouracil (5-FU) chemotherapy regimens. 5-FU is an antineoplastic antimetabolite that is widely used for the research of colorectal and pancreatic cancer[1]. Bis-Pro-5FU is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bis-pro-5fu.html
Solubility
10 mM in DMSO
Smiles
FC1=CN=C(OCC#C)N=C1OCC#C
Molecular Weight
206.17
References & Citations
[1]Catherine Adam, et al. A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):552-561.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145311/Bis-Pro-5FU-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145311/
Clinical Information
No Development Reported
CAS Number
2155827-07-7
Curated Selection
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