Heterobivalent ligand-1
Heterobivalent ligand-1 (compound 26) is a heterobivalent ligand for the Adenosine A 2A-dopamine D 2 receptor heteromer (KDB1 A2AR=2.1 nM, KDB1 D2R= 0.13 nM) [1].
Product Specifications
CAS Number
[2888568-58-7]
UNSPSC
12352005
Target
Adenosine Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/heterobivalent-ligand-1.html
Solubility
10 mM in DMSO
Smiles
O=C(CN(CC(OC)=O)CC(NCCOCCOCCOCCOCCOCCNC(COC1=CC=C(CCCN2N=CC3=C2N=C(N)N4C3=NC(C5=CC=CO5)=N4)C=C1)=O)=O)NCCOCCOCCOCCOCCOCCNC(CCC(NC6=CC=C(CCN7CN(C8=CC=CC=C8)C9(CCN(CCCC(C%10=CC=C(F)C=C%10)=O)CC9)C7=O)C=C6)=O)=O
Molecular Formula
C87H117FN16O21
Molecular Weight
1741.95
References & Citations
[1]Pulido D, et al. Heterobivalent Ligand for the Adenosine A2A-Dopamine D2 Receptor Heteromer. J Med Chem. 2022;65 (1) :616-632.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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