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DX3-235

DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-235 shows nanomolar inhibition of complex I function and ATP production in a galactose-containing medium resulting in significant cytotoxicity[1].

Product Specifications

CAS Number

[2749555-39-1]

UNSPSC

12352005

Target

Mitochondrial Metabolism; Oxidative Phosphorylation

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dx3-235.html

Solubility

10 mM in DMSO

Smiles

CC(C1=NOC(N2CCN(CC2)C([C@H]3CN(CCC3)S(=O)(C4=CC=C(C=C4)S(C(CC)CC)(=O)=O)=O)=O)=N1)C

Molecular Formula

C26H39N5O6S2

Molecular Weight

581.75

References & Citations

[1]Xue D, et al. Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors. J Med Chem. 2022;65 (1) :343-368.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-145304/DX3-235-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-145304/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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