S-MGB-234

S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT) . S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines[1].

Product Specifications

CAS Number

1970223-53-0

UNSPSC

12352005

Target

DNA/RNA Synthesis; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/s-mgb-234.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(NC(C2=CN=C(/C=C/C3=CC=C(C=C3)OC)C=C2)=O)=CN1C)NC4=CN(C)C(C(NCCC(N)=N)=O)=C4

Molecular Formula

C30H32N8O4

Molecular Weight

568.63

References & Citations

[1]Giordani F, et al. Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model [published correction appears in J Med Chem. 2021 Dec 23;64 (24) :18236]. J Med Chem. 2019;62 (6) :3021-3035.