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AL-GDa62

AL-GDa62 is a derivative of the CDH1/E-cadherin modulator SLEC-11 and induces apoptosis in CDH1-/- cells. AL-GDa62 has an EC50 of 3.2 μM and 2 μM for isogenic mammary epithelial cells MCF10A-WT (wild type) and mutant MCF10A-CDH1-/-, respectively. AL-GDa62 specifically inhibits TCOF1, ARPC5, and UBC9, and suppresses SUMOylation at low micromolar concentrations[1].

Product Specifications

CAS Number

2761538-66-1

UNSPSC

12352005

Target

Cadherin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/al-gda62.html

Solubility

10 mM in DMSO

Smiles

FC(C=C1)=CC=C1CNC2=CC(C)=NC3=C2C=C(OCCCN4CCCC4)C=C3

Molecular Formula

C24H28FN3O

Molecular Weight

393.50

References & Citations

[1]Andreas Luxenburger, et al. Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer. J Med Chem. 2021 Dec 23;64 (24) :18114-18142.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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