AL-GDa62
AL-GDa62 is a derivative of the CDH1/E-cadherin modulator SLEC-11 and induces apoptosis in CDH1-/- cells. AL-GDa62 has an EC50 of 3.2 μM and 2 μM for isogenic mammary epithelial cells MCF10A-WT (wild type) and mutant MCF10A-CDH1-/-, respectively. AL-GDa62 specifically inhibits TCOF1, ARPC5, and UBC9, and suppresses SUMOylation at low micromolar concentrations[1].
Product Specifications
CAS Number
2761538-66-1
UNSPSC
12352005
Target
Cadherin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/al-gda62.html
Solubility
10 mM in DMSO
Smiles
FC(C=C1)=CC=C1CNC2=CC(C)=NC3=C2C=C(OCCCN4CCCC4)C=C3
Molecular Formula
C24H28FN3O
Molecular Weight
393.50
References & Citations
[1]Andreas Luxenburger, et al. Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer. J Med Chem. 2021 Dec 23;64 (24) :18114-18142.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6400986-01 0.1 mL
LDB3 (LIM Domain-binding Protein 3, Protein Cypher, Z-band Alternatively Spliced PDZ-motif Protein, KIAA0613, ZASP, FLJ35865, KIAA01613, LDB3Z1, LDB3Z4) (MaxLight 750)
Sign In for Pricing
View Details MBS6400986-02 5x 0.1 mL
LDB3 (LIM Domain-binding Protein 3, Protein Cypher, Z-band Alternatively Spliced PDZ-motif Protein, KIAA0613, ZASP, FLJ35865, KIAA01613, LDB3Z1, LDB3Z4) (MaxLight 750)
Sign In for Pricing
View Details EH25241 96 Tests
Human PCSK5 (Proprotein Convertase Subtilisin/Kexin Type 5) ELISA Kit
Sign In for Pricing
View Details