OM-1700
OM-1700 is a potent tankyrase inhibitor with IC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI50=650 nM) [1].
Product Specifications
CAS Number
2406276-78-4
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/om-1700.html
Solubility
10 mM in DMSO
Smiles
FC1=[C@](C=CC=C1)[N@]2C([C@]3([H])C[C@H](C3)NC(C4=CC=CC=N4)=O)=NN=C2C5=CC=C(C=N5)OCC
Molecular Formula
C25H23FN6O2
Molecular Weight
458.49
References & Citations
[1]Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64 (24) :17936-17949.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNKS1/PARP5A; TNKS2/PARP5B
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