5-DACTHF

5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC50: 3 and 94 μM) . 5-DACTHF is a potent antitumor agent[1].

Product Specifications

CAS Number

118252-44-1

Product Name Alternative

543U76; 5,11-Methenyltetrahydrohomofolate

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-dacthf.html

Solubility

10 mM in DMSO

Smiles

OC(CC[C@@H](C(O)=O)NC(C(C=C1)=CC=C1NCCCC2=C(NC(N)=NC2=O)N)=O)=O

Molecular Formula

C19H24N6O6

Molecular Weight

432.43

References & Citations

[1]Styles, V.L. Synthesis of the penta-glutamyl derivative of N-[4-[N-[3- (2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl) -propyl]amino]benzoyl]-L-glutamic acid (5-DACTHF) . An acyclic analogue of tetrahydrofolic acid. 1990. Journal of Heterocyclic Chemistry, 27: 1809-1813.