GABAA receptor agent 5
GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 μM. GABAA receptor agent 5 shows γ-GABAAR antagonist activity with low cellular membrane permeability[1].
Product Specifications
CAS Number
1808389-92-5
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gabaa-receptor-agent-5.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CS1)NC2=CC=CC(C(N3CCC4(CC3)CCNCC4)=O)=C2
Molecular Formula
C21H25N3O2S
Molecular Weight
383.51
References & Citations
[1]Bavo F, et al. Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect. J Med Chem. 2021 Dec 23;64 (24) :17795-17812.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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