GABAA receptor agent 4

GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 μM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential[1].

Product Specifications

CAS Number

[2035203-91-7]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gabaa-receptor-agent-4.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCC2(CC1)CCNCC2)C3=CC=CC(C)=C3

Molecular Formula

C17H24N2O

Molecular Weight

272.39

References & Citations

[1]Bavo F, et al. Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect. J Med Chem. 2021 Dec 23;64 (24) :17795-17812.