Tri (TLR4-IN-C34-PEG2-amide-PEG1) -amide-C3-COOH
Tri (TLR4-IN-C34-PEG2-amide-PEG1) -amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].
Product Specifications
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tri-tlr4-in-c34-peg2-amide-peg1-amide-c3-cooh.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CCCC(NC(COCCC(NCCOCCOCCO[C@H]1[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O1)=O)(COCCC(NCCOCCOCCO[C@H]2[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O2)=O)COCCC(NCCOCCOCCO[C@H]3[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O3)=O)=O
Molecular Formula
C78H125N7O42
Molecular Weight
1832.85
References & Citations
[1]Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8 (6) :e65779. Published 2013 Jun 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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