Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH
Product Specifications
UNSPSC Description
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].
Target Antigen
PROTAC Linkers; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation;PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tri-tlr4-in-c34-c2-amide-peg1-amide-c3-cooh.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCCCCCOC1O[C@@H](COC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1NC(C)=O)CCOCC(COCCC(NCCCCCCOC2O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2NC(C)=O)=O)(COCCC(NCCCCCCOC3O[C@@H](COC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3NC(C)=O)=O)NC(CCCC(O)=O)=O
Molecular Weight
1736.85
References & Citations
[1]Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779. Published 2013 Jun 12.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145253/Tri-TLR4-IN-C34-C2-amide-PEG1-amide-C3-COOH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145253/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6318746-01 0.1 mL
MAPG8a/b (MAP1LC3A/B, MAP1LC3B, MAP1ALC3, Microtubule-associated proteins 1A/1B light chain 3B, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, Microtubule-a
Ask
View Details 
MBS6318746-02 5x 0.1 mL
MAPG8a/b (MAP1LC3A/B, MAP1LC3B, MAP1ALC3, Microtubule-associated proteins 1A/1B light chain 3B, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, Microtubule-a
Ask
View Details ![Mouse Monoclonal C1orf50 Antibody (OTI1C6) [DyLight 650]](https://cdn.genprice.uk/genprice/genprice2.png)