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Tri (TLR4-IN-C34-C2-amide-PEG1) -amide-C3-COOH

Tri (TLR4-IN-C34-C2-amide-PEG1) -amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].

Product Specifications

UNSPSC

12352005

Target

PROTAC Linkers; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tri-tlr4-in-c34-c2-amide-peg1-amide-c3-cooh.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCCCCCOC1O[C@@H](COC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1NC(C)=O)CCOCC(COCCC(NCCCCCCOC2O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2NC(C)=O)=O)(COCCC(NCCCCCCOC3O[C@@H](COC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]3NC(C)=O)=O)NC(CCCC(O)=O)=O

Molecular Formula

C78H125N7O36

Molecular Weight

1736.85

References & Citations

[1]Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8 (6) :e65779. Published 2013 Jun 12.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Alkyl/ether Linkers; TLR4

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