TLR4-IN-C34-C2-amide-C6-OH
TLR4-IN-C34-C2-amide-C6-OH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].
Product Specifications
UNSPSC
12352005
Target
PROTAC Linkers; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr4-in-c34-c2-amide-c6-oh.html
Purity
99.62
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C(NCCCCCCO)CCCCO[C@H]1[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O1
Molecular Formula
C25H42N2O11
Molecular Weight
546.61
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145245/TLR4-IN-C34-C2-amide-C6-OH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145245/TLR4-IN-C34-C2-amide-C6-OH-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; TLR4
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