TRPC5-IN-1

TRPC5-IN-1 (Compound 6j) is a selective TRPC5 inhibitor with 50.5 % Inhibition for TRPC5 at 3 μM. TRPC5-IN-1 can be used for the research of chronic kidney disease (CKD) [1].

Product Specifications

CAS Number

[2265215-18-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/trpc5-in-1.html

Purity

98.97

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(CN2C(NCC3=CC=CO3)=NC4=C2C=CC=C4)C=C1

Molecular Formula

C20H16N4O

Molecular Weight

328.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Sharma SH, et al. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg Med Chem Lett. 2019 Jan 15;29 (2) :155-159.