GR103545

GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR) . 11GR103545 is a radiotracer for imaging κ-OR in vivo[1][2].

Product Specifications

CAS Number

[126766-43-6]

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gr103545.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(/C=C/C(O)=O)=O.ClC(C=C1CC(N2[C@@H](CN(CC2)C(OC)=O)CN3CCCC3)=O)=C(C=C1)Cl

Molecular Formula

C23H29Cl2N3O7

Molecular Weight

530.40

References & Citations

[1]Hayes AG, et, al. A series of novel, highly potent and selective agonists for the kappa-opioid receptor. Br J Pharmacol. 1990 Dec;101 (4) :944-8. |[2]Talbot PS, et, al. 11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons. J Nucl Med. 2005 Mar;46 (3) :484-94.