GR103545
GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR) . 11GR103545 is a radiotracer for imaging κ-OR in vivo[1][2].
Product Specifications
CAS Number
126766-43-6
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gr103545.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(/C=C/C(O)=O)=O.ClC(C=C1CC(N2[C@@H](CN(CC2)C(OC)=O)CN3CCCC3)=O)=C(C=C1)Cl
Molecular Formula
C23H29Cl2N3O7
Molecular Weight
530.40
References & Citations
[1]Hayes AG, et, al. A series of novel, highly potent and selective agonists for the kappa-opioid receptor. Br J Pharmacol. 1990 Dec;101 (4) :944-8. |[2]Talbot PS, et, al. 11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons. J Nucl Med. 2005 Mar;46 (3) :484-94.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
κ Opioid Receptor/KOR
Available Sizes
Frequently Asked Questions
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