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HPK1-IN-16

HPK1-IN-16 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-16 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019051199A1, compound 39) [1].

Product Specifications

CAS Number

2294965-95-8

UNSPSC

12352005

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hpk1-in-16.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(C2=C(C=C(CNC)C=C2C)F)C=C3C(C4=CC=C(C5CCOCC5)C=C4)=NNC3=C1

Molecular Formula

C28H27FN4O

Molecular Weight

454.54

References & Citations

[1]Oleg VECHORKIN, et al. 6-cyano-indazole compounds as hematopoietic progenitor kinase 1 (hpk1) modulators. Patent WO2019051199A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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