HPK1-IN-15
HPK1-IN-15 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-15 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2018049200A1, compound 50) [1].
Product Specifications
CAS Number
2201098-03-3
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hpk1-in-15.html
Solubility
10 mM in DMSO
Smiles
FC(F)(C1=CC=CC(Cl)=C1C2=CC3=C(NN=C3C4=CC=C(N5CCN(CC5)C)C=C4)C=N2)F
Molecular Formula
C24H21ClF3N5
Molecular Weight
471.91
References & Citations
[1]Hai-Fen Ye, et al. Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer. Patent WO2018049200A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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