RET-IN-5
RET-IN-5 is a potent RET (rearranged during transfection) inhibitor with an IC50s of 0.4 nM and 135.1 nM for RET and VEGFR2, respectively (WO2021213476A1, compound 18) [1].
Product Specifications
CAS Number
2725770-20-5
UNSPSC
12352005
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-5.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C2C(C3=CN=C(N(C)[C@H](C4=CN=C(N5C=C(C=N5)F)C=C4)C)C=C3)=CC(OCC(C)(C)C#N)=CN2N=C1
Molecular Formula
C29H26FN9O
Molecular Weight
535.57
References & Citations
[1]Pyrazolo[1,5-a]pyridine derivative, preparation method therefor, and composition and use thereof. WO2021213476A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
