KRAS G12C inhibitor 25
KRAS G12C inhibitor 25 is a KRAS G12C inhibitor. KRAS G12C inhibitor 25 inhibits SOSl-assisted GDP/GTP exchanging activity of KRAS-G12C mutant (IC50=0.48 nM) . From WO2021216770A1 compound 3[1].
Product Specifications
CAS Number
2734060-73-0
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12c-inhibitor-25.html
Solubility
10 mM in DMSO
Smiles
CN(CCC1)[C@@H]1COC2=NC(N3C[C@@H](N(CC3)C(C=C)=O)CC#N)=C4C(C[C@@](N5C6=CC=CC=C6CCC5)([H])CC4)=N2
Molecular Formula
C32H41N7O2
Molecular Weight
555.71
References & Citations
[1]Yimin Qian, et al. Substituted tetrahydroquinazoline compounds as kras inhibitors. WO2021216770A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC471820-500 1x 500 µL
Ep-CAM / CD326 (Epithelial Marker) (rVU-1D9), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940050-500 1x 500 µL
IgA Secretory Component (SC05), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740012-500 1x 500 µL
Tyrosinase (T311), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040195-100 1x 100 µL
CD66 (CEA) (C66/195), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402342-500 1x 500 µL
Calcineurin B / PPP3R1 (CALNB/2342), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details