KRAS G12C inhibitor 23
KRAS G12C inhibitor 23 is a KRAS G12C inhibitor. KRAS G12C inhibitor 23 inhibits H358 cells with an IC50 of 491 nM (WO2021218939A1, compound 1) [1].
Product Specifications
CAS Number
2735721-00-1
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12c-inhibitor-23.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=C(N=CC=C2C)C(C)C)C3=C(OCC4=CC=CC=C45)C5=C(F)C=C3C(N6[C@H](CN(CC6)C(C=C)=O)C)=N1
Molecular Formula
C32H32FN5O3
Molecular Weight
553.63
References & Citations
[1]Fused ring compound and application thereof in medicine. WO2021218939A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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