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E3 ligase Ligand 22

E3 ligase Ligand 22 (compound 139) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway[1].

Product Specifications

CAS Number

2377849-57-3

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-22.html

Solubility

10 mM in DMSO

Smiles

CC1(CCC1)CN2CCC(CC2)N3C=C(C=N3)CNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O

Molecular Formula

C28H34N6O4

Molecular Weight

518.61

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Gesine Kerstin VEITS, et al. Cereblon binders for the degradation of ikaros. WO2019191112A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Frequently Asked Questions

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