E3 ligase Ligand 21
E3 ligase Ligand 21 (compound 2) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway[1].
Product Specifications
CAS Number
[2504233-73-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-21.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC=CC3=C2C(N1C4C(NC(CC4)=O)=O)=CC=C3CC5=CN(C6CCN(CC7(CCC7)C)CC6)N=C5
Molecular Formula
C31H35N5O3
Molecular Weight
525.64
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Gesine Kerstin VEITS, et al. Cereblon binders for the degradation of ikaros. WO2019191112A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Curated Selection
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