Tubulin inhibitor 27
Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC50 of 25.6 μM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities[1].
Product Specifications
CAS Number
184579-57-5
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-inhibitor-27.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(OC)=C(OC)C(OC)=C1)/C=C/C2=CC=NC3=CC=CC=C23
Molecular Formula
C21H19NO4
Molecular Weight
349.38
References & Citations
[1]Yao Y, et al. Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :652-665.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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