Gü1303
Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK) . Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1].
Product Specifications
CAS Number
1043922-53-7
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/g-1303.html
Solubility
10 mM in DMSO
Smiles
CN(N(C([C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)C)C#N
Molecular Formula
C20H22N4O3
Molecular Weight
366.41
References & Citations
[1]Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :515-526.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin K
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