CDK2-IN-8

CDK2-IN-8 is a potent CDK2 inhibitor with an IC50 of 1.74 μM. CDK2-IN-8 shows antiproliferative activity. CDK2-IN-8 has the potential for the research of melanoma[1].

Product Specifications

CAS Number

[2919216-36-5]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk2-in-8.html

Solubility

10 mM in DMSO

Smiles

O=C(NN1C(COC2=CC=CC=C2)=NC3=C(C=CC=C3)C1=O)CN4CCN(C)CC4

Molecular Formula

C22H25N5O3

Molecular Weight

407.47

References & Citations

[1]Mohammed ER, et al. Development of newly synthesised quinazolinone-based CDK2 inhibitors with potent efficacy against melanoma. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :686-700.