Anticancer agent 40

Anticancer agent 40 (compound 3e) is a potent anticancer agent. Anticancer agent 40 shows anticancer activities with IC50s of 0.94, 0.98, 0.96, 0.95, 2.13 nM for SKBR-3, SKOV-3, PC-3, U-87, HDF cells, respectively[1].

Product Specifications

CAS Number

[2760658-33-9]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-40.html

Solubility

10 mM in DMSO

Smiles

CC(N[C@H]1CCC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C(OC/C=C/C)C(C=C3)=O)=O

Molecular Formula

C25H29NO6

Molecular Weight

439.50

References & Citations

[1]Pyta K, et al. Regioselective approach to colchiceine tropolone ring functionalization at C (9) and C (10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :597-605.