Tubulin inhibitor 22
Tubulin inhibitor 22 (compound 4c) is a potent inhibitor of tubulin with anti-angiogenesis and anti-cancer properties. Tubulin inhibitor 22 arrests MGC-803 cell cycle at G2/M phase. Tubulin inhibitor 22 dose-dependently causes Caspase-induced apoptosis of MGC-803 cells through mitochondrial dysfunction[1].
Product Specifications
CAS Number
3033038-38-6
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-inhibitor-22.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(OC)=C(OC)C(OC)=C1)/C(F)=C/C2=CNC3=C2C=CC(Br)=C3
Molecular Formula
C20H17BrFNO4
Molecular Weight
434.26
References & Citations
[1]Sun M, et al. Identification of novel non-toxic and anti-angiogenic α-fluorinated chalcones as potent colchicine binding site inhibitors. J Enzyme Inhib Med Chem. 2022;37 (1) :339-354.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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