VEGFR-2-IN-15
VEGFR-2-IN-15 (Compound 14b) is a potent VEGFR-2 inhibitor. VEGFR-2-IN-15 arrests the HepG2 cell growth at the Pre-G1 phase and induces apoptosis[1].
Product Specifications
CAS Number
3033033-20-1
UNSPSC
12352005
Target
Apoptosis; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-15.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC=C1OC)C2=CC=C(NC(CSC3=NC4=CC(Cl)=CC=C4O3)=O)C=C2
Molecular Formula
C23H18ClN3O4S
Molecular Weight
467.92
References & Citations
[1]Elkady H, et al. New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :397-410.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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