EGFR-IN-46
EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM and 14.25 nM, respectively. EGFR-IN-46 is a potent anti-cancer agent. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis[1].
Product Specifications
CAS Number
2764772-88-3
UNSPSC
12352005
Target
Apoptosis; EGFR; FAK
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-46.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2C(N=C(C=C2OCCCNC3CCN(CC3)C)C4=CC=C(C=C4)C(F)(F)F)=C1)OC
Molecular Formula
C27H32F3N3O3
Molecular Weight
503.56
References & Citations
[1]Elbadawi MM, et al. 2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :349-372.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
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