CXCR2 antagonist 6
CXCR2 antagonist 6 (compound 35c) is a potent CXCR2 antagonist. CXCR2 antagonist 6 shows potent CXCR2 binding affinity (IC50=0.044 µM) and calcium mobilization (IC50=0.66 µM) [ 1].
Product Specifications
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cxcr2-antagonist-6.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](NC1=C2C=CN=CC2=NC(SCC3=CC=CC(F)=C3F)=N1)CO
Molecular Formula
C17H16F2N4OS
Molecular Weight
362.40
References & Citations
[1]Van Hoof M, et al. Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[4,5-d]pyrimidine. Eur J Med Chem. 2022; 235:114268.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR2
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