HDAC10-IN-2

HDAC10-IN-2 (compound 10c) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. HDAC10-IN-2 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells[1].

Product Specifications

UNSPSC

12352005

Target

Autophagy; HDAC

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac10-in-2.html

Solubility

DMSO : 75 mg/mL (ultrasonic)

Smiles

O=C(NO)/C=C/C1CCN(CC1)CC2=CC=CC3=C2C=CC=C3

Molecular Formula

C19H22N2O2

Molecular Weight

310.39

References & Citations

[1]Zeyen P, et al. Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur J Med Chem. 2022 Apr 15;234:114272.