IDO1/TDO-IN-1
IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].
Product Specifications
CAS Number
2379527-72-5
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ido1-tdo-in-1.html
Solubility
10 mM in DMSO
Smiles
CC(OCC1=COC2=C1C(C(C3=C2C=CC4=C3C=CC(C4(C)C)=O)=O)=O)=O
Molecular Formula
C21H16O6
Molecular Weight
364.35
References & Citations
[1]Jiangxin Liu, et al. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. Eur J Med Chem. 2022 May 5;235:114294.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDO1
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