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SARS-CoV-2-IN-15

SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

Product Specifications

CAS Number

1580-42-3

UNSPSC

12352005

Hazard Statement

H315, H320, H335

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sars-cov-2-in-15.html

Purity

99.65

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC(Cl)=CC=C2O

Molecular Formula

C14H9ClF3NO2

Molecular Weight

315.67

Precautions

H315, H320, H335

References & Citations

[1] Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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