SDOX
SDOX is the Doxorubicin (DOX) proagent. The loaded DOX proagents (SDOX) which can release the parent agents DOX triggered by excessive GSH in tumor cells, minimize the unexpected side effects on normal tissues without compromising the potency[1].
Product Specifications
CAS Number
2921601-78-5
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sdox.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OCCOCCOCCOC(CCC(OCCSSCCOC(N[C@H]4C[C@@H](O[C@H]([C@H]4O)C)O[C@@H]5C6=C(C[C@](O)(C5)C(CO)=O)C(O)=C7C(C(C8=C(OC)C=CC=C8C7=O)=O)=C6O)=O)=O)=O)([H])[C@@]9([H])[C@](CC3)([C@@](CC9)([H])[C@H](C)CCCC(C)C)C
Molecular Formula
C69H97NO20S2
Molecular Weight
1324.63
References & Citations
[1]Yi Zhao, et a l. pH-redox responsive cascade-targeted liposomes to intelligently deliver doxorubicin prodrugs and lonidamine for glioma. Eur J Med Chem. 2022 May 5;235:114281.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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