ATX inhibitor 13
Product Specifications
UNSPSC Description
ATX inhibitor 13 (10c) is an orally active and potent ATX inhibitor, with an IC50 of 3.4 nM. ATX inhibitor 13 inhibits proliferation and migration, and induces apoptosis and G2 phase arrest in RAW264.7 cells. ATX inhibitor 13 suppresses tumor cell colony formation[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atx-inhibitor-13.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=CC(Cl)=CC(Cl)=C1)NC2=C(CC)N=C3C(C)=CC(C4=CC=C(CN5CCN(CCO)CC5)C=C4)=CN32
Molecular Weight
596.55
References & Citations
[1]Lei H, et al. Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors. Eur J Med Chem. 2022;236:114307.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144766/ATX-inhibitor-13-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144766/
Clinical Information
No Development Reported
CAS Number
2485779-34-6
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