5-HT1A antagonist 1
5-HT1A antagonist 1 (compound 6f) is a potent and selective antagonist of 5-HT1A receptor, with a Ki of 35 nM. 5-HT1A antagonist 1 can be used for the research of CNS diseases[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-ht1a-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(CC1)C2=CC(Cl)=CC=C2)NCCCCCCN3N=C4C=CC=CN4C3=O
Molecular Formula
C23H29ClN6O2
Molecular Weight
456.97
References & Citations
[1]Zaręba P, et, al. New N-aryl-N'-aryl-/ (thio) ureido-/sulfamoylamino-derivatives of alkyl/alkylcarbamoyl piperazines: Effect of structural modifications on selectivity over 5-HT 1A receptor. Eur J Med Chem. 2022 May 5;235:114319. Eur J Med Chem. 2022 May 5;235:114319.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3; MUC3; α-1 microglobulin
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