EGFR-IN-3
EGFR-IN-3 (Compound 4c) is a potent EGFR inhibitor with an IC50 of 0.32 µM against EGFRwt-TK. EGFR-IN-3 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].
Product Specifications
CAS Number
[3031812-65-1]
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-3-11.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(NC2=NC(NC3=CC=C(NC(C4=CC=CC(F)=C4)=O)C=C3)=NC=C2C(F)(F)F)SC=C1)NC
Molecular Formula
C24H18F4N6O2S
Molecular Weight
530.50
References & Citations
[1]Yan L, et al. Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :832-843.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
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