cSPM
Product Specifications
UNSPSC Description
cSPM (Cyclic spermine) is a Aβ42 inhibitor. cSPM could suppress the aggregation of three different peptides, Aβ42, amylin and insulin, and decreases cytotoxicity[1].
Target Antigen
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cspm.html
Solubility
10 mM in DMSO
Smiles
CCCCNCCCCN1CCCN2CCC3N(CCCN3CCC12)CCCCNCCCN
Molecular Weight
479.79
References & Citations
[1]Kunitomi R, et, al. Inhibition of amyloid formation of amyloid β (1-42), amylin and insulin by 1,5-diazacyclooctanes, a spermine-acrolein conjugate. Bioorg Med Chem. 2021 Sep 15;46:116391.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144752/cSPM-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144752/
Clinical Information
No Development Reported
Curated Selection
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