CSPM

CSPM (Cyclic spermine) is a Aβ42 inhibitor. cSPM could suppress the aggregation of three different peptides, Aβ42, amylin and insulin, and decreases cytotoxicity[1].

Product Specifications

Product Name Alternative

Cyclic spermine

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cspm.html

Solubility

10 mM in DMSO

Smiles

CCCCNCCCCN1CCCN2CCC3N(CCCN3CCC12)CCCCNCCCN

Molecular Formula

C27H57N7

Molecular Weight

479.79

References & Citations

[1]Kunitomi R, et, al. Inhibition of amyloid formation of amyloid β (1-42), amylin and insulin by 1,5-diazacyclooctanes, a spermine-acrolein conjugate. Bioorg Med Chem. 2021 Sep 15;46:116391.