PD-1/PD-L1-IN-26
PD-1/PD-L1-IN-26 (Compound II-14) is a potent inhibitor of PD-1/PD-L1 with an IC50 of 0.0380 μM. PD-1/PD-L1-IN-26 activates the immune microenvironment by promoting the infiltration of CD4+ T cells into tumor tissues. PD-1/PD-L1-IN-26 has the potential for the research of cancer diseases[1].
Product Specifications
CAS Number
2966090-78-6
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-26.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C=CC=C1C2=CC=CC(OCCCN3CCC(CC3)CO)=C2)COC4=CC=C(C(OCC5=NN=C(O5)C6=CC=CC=C6)=C4)CNC(CO)(CO)CO
Molecular Formula
C43H52N4O8
Molecular Weight
752.89
References & Citations
[1]Fang L, et al. Discovery of 1,3,4-oxadiazole derivatives as potential antitumor agents inhibiting the programmed cell death-1/programmed cell death-ligand 1 interaction. Bioorg Med Chem. 2021 Sep 15;46:116370.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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