NS2B/NS3-IN-5
NS2B/NS3-IN-5 (Compound 25b) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 0.67 µM and 4.38 µM against ZIKV and DENV2 NS2B/NS3 proteases, respectively[1].
Product Specifications
CAS Number
[2910757-21-8]
UNSPSC
12352005
Target
Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ns2b-ns3-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)I)NC2=NC3=CC(O)=C(C=C3S2)O
Molecular Formula
C14H9IN2O3S
Molecular Weight
412.20
References & Citations
[1]Maus H, et al. SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases. Bioorg Med Chem. 2021 Oct 1;47:116392.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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