Pantothenate kinase-IN-1
Pantothenate kinase-IN-1 (Compound 1) is a pantothenate kinase (PANK) modulator with an IC50 of 0.51 µM against PANK3. Pantothenate kinase-IN-1 has a reasonable ligand efficiency (LipE = 2.8) [1].
Product Specifications
CAS Number
[1024168-48-6]
UNSPSC
12352005
Target
PANK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pantothenate-kinase-in-1.html
Purity
98.20
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C1=CC=C(C=C1)NC(N2CCN(CC2)C3=NC=C(C=C3)C#N)=O)C
Molecular Formula
C21H25N5O
Molecular Weight
363.46
References & Citations
[1]Sharma LK, et al. LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators. Bioorg Med Chem. 2021 Dec 15;52:116504.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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