Gp120-IN-2

Gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC50 of 7.5 µM and CC50 of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells[1].

Product Specifications

CAS Number

[123629-42-5]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gp120-in-2.html

Solubility

10 mM in DMSO

Smiles

CCOC(C1=C(NC(NC1C2=CC(OC)=C(C=C2)O)=O)C)=O

Molecular Formula

C15H18N2O5

Molecular Weight

306.31

References & Citations

[1]Senapathi J, et al. Design, Synthesis, and Antiviral activity of 1,2,3,4-Tetrahydropyrimidine derivatives acting as novel entry inhibitors to target at "Phe43 cavity" of HIV-1 gp120. Bioorg Med Chem. 2021 Dec 15;52:116526.