Anti-inflammatory agent 11

Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1].

Product Specifications

CAS Number

[63932-07-0]

UNSPSC

12352005

Target

Bacterial; TNF Receptor

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-11.html

Solubility

10 mM in DMSO

Smiles

[H]N(C(N(NC(C1=CC=NC=C1)=O)[H])=S)CC2=CC=CC=C2

Molecular Formula

C14H14N4OS

Molecular Weight

286.35

References & Citations

[1]Calixto SD, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506.