HDAC1/6-IN-1
Product Specifications
UNSPSC Description
HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion[1].
Target Antigen
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac1-6-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2C(N=C(N=C2NC3CCN(CC3)CC4=CC=CC=C4)N5CCN(CC5)CCCCCC(NO)=O)=C1)OC
Molecular Weight
591.74
References & Citations
[1]Zheng H, et al. Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents. Bioorg Med Chem. 2022 Jan 1;53:116524.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144725/HDAC1-6-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144725/
Clinical Information
No Development Reported
CAS Number
2630989-02-3
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