HSP90-IN-10

HSP90-IN-10 (Compound 16s) is a potent inhibitor of HSP90. HSP90-IN-10 exhibits high antiproliferative potency against HCC1954 breast cancer cells with the IC50 value of 6 µM. HSP90-IN-10 does not inhibit the growth of normal epithelial cells. HSP90-IN-10 also induces apoptosis[1].

Product Specifications

CAS Number

[2881071-86-7]

UNSPSC

12352005

Target

Apoptosis; HSP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hsp90-in-10.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(C2=C3C(CC(C)(C/C3=N\OC(C4=CC(NC(C5=CC(F)=CC=C5)=O)=CC=C4)=O)C)=NO2)=CC=C1O

Molecular Formula

C30H26FN3O6

Molecular Weight

543.54

References & Citations

[1]Piven YA, et al. Novel O-acylated (E) -3-aryl-6,7-dihydrobenzisoxazol-4 (5H) -one oximes targeting HSP90-HER2 axis in breast cancer cells. Bioorg Med Chem. 2022 Jan 1;53:116521.